DMT

Brand

MS type

format

dosing

alemtuzumab

Lemtrada

highly active RRMS;

RESMS

infusion

a 5-day course followed 12 months later with a 3-day course; one or two further 3-day courses can be given, if needed, at least a year apart

cladribine

Mavenclad

highly active relapsing forms of MS

tablets

a 4-5 day course and then a gap, with the total dose given over two years in weeks 1, 5, 53, 57

dimethyl fumarate

Tecfidera + generics

RRMS

tablets

twice daily

diroximel fumarate

Vumerity

RRMS

capsules

twice daily

fingolimod

Gilenya + generics

highly active RRMS;

RESRM

capsules

once daily

glatiramer acetate

Copaxone;

Brabio (generic version)

relapsing forms of MS

(not for PPMS or SPMS)

subcutaneous injection

either once daily or three times a week by self-administration

interferon beta 1a

Avonex,

Rebif

relapsing forms of MS (not for progressive MS);

single demyelinating events with an active inflammatory process

intramuscular injection

subcutaneous injection

i/m injection once weekly

s/c injection three times a week

interferon beta 1b

Betaferon

(Extavia – discontinued)

RRMS;

SPMS;

single demyelinating events with an active inflammatory process

subcutaneous injection

every other day

natalizumab

Tysabri;

Tyruko (biosimilar version)

highly active RRMS, RESMS

intravenous infusion or subcutaneous injection

every four weeks

ocrelizumab

Ocrevus

relapsing forms of MS;

early PPMS

intravenous infusion or subcutaneous injection

every six months (a minimum of 5 months between doses)

ofatumumab

Kesimpta

relapsing forms of MS

subcutaneous injection

monthly (once loading doses have been given)

ozanimod

Zeposia

RRMS

capsules

once daily

peginterferon beta 1a

Plegridy

relapsing forms of MS

injection

subcutaneous or intramuscular injection every two weeks

ponesimod

Ponvory

relapsing forms of MS

tablet

once daily

siponimod (as siponimod fumaric acid)

Mayzent

SPMS

tablets

once daily

teriflunomide

Aubagio + generics

RRMS

tablets

once daily

ublituximab

Briumvi

relapsing forms of MS

infusion

day 1, day 14 and then every 24 weeks