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All links accessed on August 9 2025

1. NICE Clinical Guideline CG156. ‘Fertility problems: assessment and treatment’. Published February 2013, last updated September 2017. https://www.nice.org.uk/guidance/cg156

2. World Health Organization. Infertility. May 22nd 2024. https://www.who.int/news-room/fact-sheets/detail/infertility

3. RB Leaver. ‘Male infertility: an overview of causes and treatment options’. Br J Nurs. October 13 2016. 25;18:S35-S40. https://www.magonlinelibrary.com/doi/abs/10.12968/bjon.2016.25.18.S35

4. K Skoracka et al. ‘Diet and Nutritional Factors in Male (In)fertility—Underestimated Factors’. J. Clin. Med. May 9 2020. 9;5:1400. https://www.mdpi.com/2077-0383/9/5/1400

5. British Nutrition Foundation. Male fertility. Page last reviewed September 2018. https://www.nutrition.org.uk/nutrition-for/men/male-fertility/

6. Macmillan Cancer Support. Cancer information and support: fertility and cancer treatment. Last reviewed April 1 2023/. shttps://www.macmillan.org.uk/cancer-information-and-support/impacts-of-cancer/fertility/cancer-treatments

7. Human Fertilisation & Embryology Authority (HFEA). Fertility drugs. Next review date June 2027. https://www.hfea.gov.uk/treatments/explore-all-treatments/fertility-drugs/

8. The Pituitary Foundation. Male Hormones and Fertility. https://www.pituitary.org.uk/information/male-hormones-and-fertility/

9. The British Association of Urological Surgeons (BAUS). Fertility problems. Page dated March 2024.  https://www.baus.org.uk/patients/conditions/4/fertility_problems

10. NHS Health A to Z. Infertility. Last updated August 9 2023. https://www.nhs.uk/conditions/infertility/

11. NHS Health A to Z. Klinefelter syndrome. Last updated February 20 2023. https://www.nhs.uk/conditions/klinefelters-syndrome/

12. Fertility Network UK. Himfertility. https://fertilitynetworkuk.org/himfertility/

13. Y Lui et al. ‘Sexual Dysfunction in Infertile Men: A Systematic Review and Meta-Analysis’. Sexual Medicine. August 2022. 10;4:100528. https://academic.oup.com/smoa/article/10/4/100528/6956784

14. BAUS. Erectile dysfunction (impotence). Page dated June 2024. https://www.baus.org.uk/patients/conditions/3/erectile_dysfunction_impotence

15. S Gupta et al. ‘A Comprehensive Guide to Sperm Recovery in Infertile Men with Retrograde Ejaculation’. World J Men’s Health. April 2022. 40;2:208-216. https://wjmh.org/DOIx.php?id=10.5534/wjmh.210069

16. NHS Health A to Z. Ejaculation problems. Last updated February 9 2023. https://www.nhs.uk/conditions/ejaculation-problems/

17. Y Guo et al. ‘Correlation between viral infections in male semen and infertility: a literature review’. Virology Journal. 2024. Vol 21; Article number: 167. https://virologyj.biomedcentral.com/articles/10.1186/s12985-024-02431-w

18. K Khalafalla et al. ‘Are sexually transmitted infections associated with male infertility? A systematic review and in-depth evaluation of the evidence and mechanisms of action of 11 pathogens’. Arab Journal of Urology. 2023. 21;4:216–232. https://www.tandfonline.com/doi/full/10.1080/2090598X.2023.2218566

19. HFEA. Treatments. Published April 30 2025.  https://www.hfea.gov.uk/treatments/

20. J Ding et al. ‘FDA-approved medications that impair human spermatogenesis’. Oncotarget. 2017. 8:10714-10725. https://www.oncotarget.com/article/12956/text/

21. Y Duca et al. ‘Substance Abuse and Male Hypogonadism’. J. Clin. Med. May 2019. 8;5:732. https://www.mdpi.com/2077-0383/8/5/732

22. Medicines and Healthcare products Regulatory Agency. ‘Traditional Chinese medicines containing lei gong teng (tripterygium wilfordii)’. December 11 2014. https://www.gov.uk/drug-safety-update/traditional-chinese-medicines-containing-lei-gong-teng-tripterygium-wilfordii

23. Prostate Cancer Uk. Hormone therapy. Updated November 2024. https://prostatecanceruk.org/prostate-information-and-support/treatments/hormone-therapy

24. Cancer Research UK. Men’s fertility and chemotherapy. Last reviewed January 9 2024. https://www.cancerresearchuk.org/about-cancer/treatment/chemotherapy/fertility/men

25. The Royal Marsden NHS Foundation Trust. Chemotherapy side effects: fertility and pregnancy. https://www.royalmarsden.nhs.uk/your-care/treatments/chemotherapy/chemotherapy-effects-and-side-effects/fertility-pregnancy

26. HFEA. Fertility drugs. Next review date June 2 2027. https://www.hfea.gov.uk/treatments/explore-all-treatments/fertility-drugs/

27. M Hujiben et al. ‘Clomiphene citrate for male infertility: A systematic review and meta-analysis’. Andrology. September 2023. 11;6:987-996.  https://onlinelibrary.wiley.com/doi/10.1111/andr.13388

28. A Alamo et al. ‘Environment and Male Fertility: Effects of Benzo-α-Pyrene and Resveratrol on Human Sperm Function In Vitro’. J. Clin. Med. April 2019. 8;4:561. https://www.mdpi.com/2077-0383/8/4/561

29. B Salehi et al. ‘Resveratrol: A Double-Edged Sword in Health Benefits’. Biomedicines. September 2018. 6;3:91. https://www.mdpi.com/2227-9059/6/3/91

30. E Illiano et al. ‘Resveratrol-Based Multivitamin Supplement Increases Sperm Concentration and Motility in Idiopathic Male Infertility: A Pilot Clinical Study’. J. Clin. Med. December 2020. 9;12:4017. https://www.mdpi.com/2077-0383/9/12/4017

31. HFEA. Surgical sperm extraction. Next review date June 2027. https://www.hfea.gov.uk/treatments/explore-all-treatments/surgical-sperm-extraction/

32. NHS Cambridge University Hospital. Sperm retrieval from vas deferens or epididymis: PESA – Information for patients. https://www.cuh.nhs.uk/patient-information/sperm-retrieval-from-vas-deferens-or-epididymis-pesa-information-for-patients/

 

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