Cochrane meta-analyses of randomised controlled trials (RCTs) have indicated:

·       reducing total fat intake (with no intention to lose weight) consistently leads to a small but stable weight loss, averaging 1.4kg, with reduced BMI, waist circumference and percentage body fat26

·       off-label use of fluoxetine may decrease weight (an average of 2.7kg) compared to placebo, albeit with low or very low overall certainty of evidence27

·       surgery leads to greater weight loss and improvement in comorbidities compared to non-surgical interventions, with Roux-en-Y gastric bypass and gastric sleeves generally better than adjustable gastric banding.