Analysis of FRIDs use in older people suggests that being prescribed two or more STOPPFall-listed medications could increase the odds of a fall by 86%. Falls which cause injuries such as hip fractures are also more likely.¹⁷

Common mechanisms involved in medicines-related falls include:^9,18,19

·      sedation with slowed reaction times or impaired balance;

·      reduced blood pressure including orthostatic hypotension when standing up

·      common fainting (vasovagal syndrome) 

·      vasodepressor carotid sinus hypersensitivity resulting in an exaggerated response of hypersensitive pressure receptors (baroreceptors) causing fainting when the carotid sinus in the neck is stimulated by increased pressure or stretching;

·      heart rhythm changes (bradycardia, tachycardia or asystole).