This site is intended for Healthcare Professionals only
CPD module: Pharmacogenomics
Azathioprine
Keep going!
(
Azathioprine
In some people, a genetic variation means individuals lack the enzyme thiopurine S-methyltransferase (TPMT), which means azathioprine cannot be converted it into its active form. Azathioprine can then build up in bone marrow destroying white blood cells and making the person more prone to infection. People with rheumatoid arthritis can be tested for the gene expressing TPMT as well as the TPMT enzyme itself to see whether azathioprine would be effective.17
Don’t worry, you can come back and finish the assessment in your own time.
