Antibiotic advance hailed in fight to beat superbugs
Scientists at The Scripps Research Institute (TSRI) have given new superpowers to a lifesaving antibiotic called vancomycin, an advance that could eliminate the threat of antibiotic-resistant infections.Â
The researchers, led by Dale Boger, co-chair of TSRI's Department of Chemistry, discovered a way to structurally modify vancomycin to make an already-powerful version of the antibiotic even more potent.
"Doctors could use this modified form of vancomycin without fear of resistance emerging," said Boger, whose team announced the finding today in the journal Proceedings of the National Academy of Sciences.
The original form of vancomycin has been prescribed for 60 years, and bacteria are only now developing resistance to it.Â
Boger called vancomycin "magical" for its proven strength against infections, and previous studies by Boger and his colleagues at TSRI had shown that it is possible to add two modifications to vancomycin to make it even more potent. "With these modifications, you need less of the drug to have the same effect," Boger said.
The new study shows that scientists can make a third modification â€“which interferes with a bacterium's cell wall in a new way â€“ with promising results. Combined with the previous modifications, this alteration gives vancomycin a 1,000-fold increase in activity, meaning doctors would need to use less of the antibiotic to fight infection.
The discovery makes this version of vancomycin the first antibiotic to have three independent mechanisms of action.Â
"This increases the durability of this antibiotic," said Boger. "Organisms just can't simultaneously work to find a way around three independent mechanisms of action. Even if they found a solution to one of those, the organisms would still be killed by the other two."
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